Perlane adds volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Like Restylane®, Perlane® is a clear gel formulation of hyaluronic acid that is specifically formulated to add volume like your body’s own hyaluronic acid. What makes Perlane® different is the average size of the particles and the depth of injection. On average, the gel particles in Perlane® are larger than those in Restylane®, which makes Perlane® a good choice for wrinkles that benefit from a deeper injection into the skin. In three clinical studies of 150 patients each, on average 70% of patients maintained improvement for six months after just one Perlane® treatment.